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Article

Ubiquitin-Binding Protein CG5445 Suppresses Aggregation and Cytotoxicity of Amyotrophic Lateral Sclerosis-Linked TDP-43 in Drosophila.

Molecular and cellular biology - 1 Feb 2018

Uechi Hiroyuki, Kuranaga Erina, Iriki Tomohiro, Takano Kohei, Hirayama Shoshiro, Miura Masayuki, Hamazaki Jun, Murata Shigeo

Abstract excerpt

Ubiquitin-mediated protein degradation plays essential roles in proteostasis and is involved in the pathogenesis of neurodegenerative diseases in which ubiquitin-positive aberrant proteins accumulate. However, how such aberrant proteins are processed inside cells has not been fully explored. Here, we show that the product of CG5445, a previously uncharacterized Drosophila gene, prevents the accumulation of...

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Identifiers

PMID: 29109084
DOI: 10.1128/MCB.00195-17
PMCID: PMC5770533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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