Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-1R8 silencing improves the anti-tumor function of freshly isolated human NK cells

1 Mar 2022

Abstract excerpt

The inhibitory receptor interleukin-1 receptor 8 (IL-1R8) has been recently recognized to be expressed also by human natural killer (NK) cells. This study was aimed to design and optimize IL-1R8 silencing conditions in human NK cells to precisely establish the activity of such receptor in these cells. Electroporation of freshly isolated or IL-2-cultured NK cells with small interfering RNA (siRNA), resulted in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35292515
DOI: 10.1136/jitc-2021-003858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-1R8 silencing improves the anti-tumor function of freshly isolated human NK cellsPMID 35292515Read ↗

IL-1R8 : a novel checkpoint regulating anti-tumor and anti-viral activity of NK cellsSemantic proximity Read ↗

IL-1R8: A molecular brake of anti-tumor and anti-viral activity of NK cells and ILCSemantic proximity Read ↗

Human natural killer cellsSemantic proximity Read ↗

Human NK cells and cancerSemantic proximity Read ↗

The NK-92 cell line—30 years later: its impact on natural killer cell research and treatment of cancerSemantic proximity Read ↗

Bringing natural killer cells to the clinic: ex vivo manipulationSemantic proximity Read ↗

KIR downregulation by IL‐12/15/18 unleashes human NK cells from KIR/HLA‐I inhibition and enhances killing of tumor cellsSemantic proximity Read ↗

Natural Born Killers: NK Cells in Cancer TherapySemantic proximity Read ↗

IL-1R8 acts as an immune checkpoint in CD8⁺ T CellsSemantic proximity Read ↗

Human NK receptors: From the molecules to the therapy of high risk leukemiasSemantic proximity Read ↗

The Natural Killer Cell Line NK-92 and Its Genetic Variants: Impact on NK Cell Research and Cancer ImmunotherapySemantic proximity Read ↗

Natural killer cell‐based immunotherapy in cancer: current insights and future prospectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.