Article
BRAF V600E, TERT promoter mutations and CDKN2A/B homozygous deletions are frequent in epithelioid glioblastomas: a histological and molecular analysis focusing on intratumoral heterogeneity.
Brain pathology (Zurich, Switzerland) - 1 Sept 2018
Nakajima Nozomi, Nobusawa Sumihito, Nakata Satoshi, Nakada Mitsutoshi, Yamazaki Tatsuya, Matsumura Nozomi, Harada Kenichi, Matsuda Hadzki, Funata Nobuaki, Nagai Shoichi, Nakamura Hideo, Sasaki Atsushi, Akimoto Jiro, Hirato Junko, Yokoo Hideaki
Abstract excerpt
Epithelioid glioblastoma (E-GBM) is a rare aggressive variant of IDH-wildtype glioblastoma newly recognized in the 2016 World Health Organization classification, composed predominantly of monotonous, patternless sheets of round cells with laterally positioned nuclei and plump eosinophilic cytoplasm. Approximately 50% of E-GBM harbor BRAF V600E, which is much less frequently found in other types of glioblastomas....
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