Article
Additional genetic alterations in BRAF-mutant gliomas correlate with histologic diagnoses.
Journal of neuro-oncology - 1 Sept 2020
Dono Antonio, Vu Jennifer, Anapolsky Molly, Hines Gabriella, Takayasu Takeshi, Yan Yuanqing, Tandon Nitin, Zhu Jay-Jiguang, Bhattacharjee Meenakshi B, Esquenazi Yoshua, Ballester Leomar Y
Abstract excerpt
INTRODUCTION: Recently, the term "Diffuse glioma, BRAF V600E-mutant" has been recommended for IDH-wildtype gliomas with BRAF p.V600E mutation and without CDKN2A/B deletion. However, additional alterations in gliomas that coexist with BRAF-mutations are poorly defined. METHODS: We analyzed next-generation sequencing results in 315 cancer-associated genes for 372 gliomas from our institution (2010 to 2017). In...
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