Article
Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis.
Brain pathology (Zurich, Switzerland) - 1 Sept 2018
Korshunov Andrey, Chavez Lukas, Sharma Tanvi, Ryzhova Marina, Schrimpf Daniel, Stichel Damian, Capper David, Sturm Dominik, Kool Marcel, Habel Antje, Kleinschmidt-DeMasters Bette K, Rosenblum Marc, Absalyamova Oksana, Golanov Andrey, Lichter Peter, Pfister Stefan M, Jones David T W, Perry Arie, von Deimling Andreas
Abstract excerpt
Epithelioid glioblastoma (eGBM) is a newly defined and rare GBM variant in the current WHO 2016 classification. BRAF V600E mutation is overrepresented in these tumors and there is known some morphological overlap with anaplastic epithelioid PXA (ePXA). In order to further elucidate this diagnostic category, we molecularly characterized 64 pediatric and adult examples initially diagnosed as "eGBM." Tumors were...
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