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Conditioned media from the renal cell carcinoma cell line 786.O drives human blood monocytes to a monocytic myeloid-derived suppressor cell phenotype.

Cellular immunology - 1 Jan 2018

Okada Shannon L, Simmons Randi M, Franke-Welch Secil, Nguyen Thuy H, Korman Alan J, Dillon Stacey R, Gilbertson Debra G

Abstract excerpt

Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells critical in mediating immune suppression in cancer patients. To develop an in vitro assay system that functionally mimics the tumor microenvironment, we cultured human monocytes with conditioned media from several cancer cell lines. Conditioned media from five tumor cell lines induced survival and differentiation of monocytes into cells...

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Identifiers

PMID: 29103587
DOI: 10.1016/j.cellimm.2017.10.014

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STAT3

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