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Article

Human CD16+ monocytes promote a pro-atherosclerotic endothelial cell phenotype via CX3CR1-CX3CL1 interaction.

Cardiovascular research - 25 May 2021

Roy-Chowdhury Eva, Brauns Nicolas, Helmke Alexandra, Nordlohne Johannes, Bräsen Jan Hinrich, Schmitz Jessica, Volkmann Julia, Fleig Susanne V, Kusche-Vihrog Kristina, Haller Hermann, von Vietinghoff Sibylle

Abstract excerpt

AIMS: Monocytes are central for atherosclerotic vascular inflammation. The human non-classical, patrolling subtype, which expresses high levels of CD16 and fractalkine receptor CX3CR1, strongly associates with cardiovascular events. This is most marked in renal failure, a condition with excess atherosclerosis morbidity. The underlying mechanism is not understood. This study investigated how human CD16+ monocytes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32717023
DOI: 10.1093/cvr/cvaa234

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