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Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress

24 Jan 2013

Abstract excerpt

Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases. This pathology causes a significant loss of dopaminergic neurons in the Substantia Nigra. Several reports have claimed a role of defective nuclear and mitochondrial DNA repair pathways in PD etiology, in particular, of the Base Excision Repair (BER) system. In addition, recent findings, related to PD progression, indicate...

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PMID: 23348931
DOI: 10.3390/ijms14022388

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