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Article

Prostate cancer germline variants with therapeutic implications.

Trends in molecular medicine - 1 May 2026

Bitaraf Masoud, Castro Elena, Sharifi Nima

Abstract excerpt

Prostate cancer, the most prevalent noncutaneous cancer and the second leading cause of cancer death among men, is highly heritable. Germline alterations in genes involved in DNA damage repair and the androgen synthesis pathway are associated with worse outcomes. Pathogenic variants in BRCA1, BRCA2, and HSD3B1 are the most prevalent alterations in men with advanced prostate cancer and are associated with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40744833
DOI: 10.1016/j.molmed.2025.07.004
PMCID: PMC12321213

Genes

BRCA1
HSD3B1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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