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Article

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

2018-06-28

Abstract excerpt

The sirtuins are highly conserved nicotinamide adenine dinucleotide (NAD + )-dependent enzymes that play a broad role in cellular metabolism and aging. Mitochondrial sirtuin 3 (SIRT3) is downregulated in aging and age-associated diseases such as cancer and neuro-degeneration and plays a major role in maintaining mitochondrial function and preventing oxidative stress. Mitochondria dysfunction is central to the pat...

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Literature Corpus work
f8c4a8db-b42a-5c10-9c09-318a2ea377a0
DOI
10.1101/357624
Open publication

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Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathwayDOI 10.1101/357624
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