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Comparative evolution of influenza A virus H1 and H3 head and stalk domains across host species

11 Dec 2023

Abstract excerpt

ABSTRACT The influenza A virus hemagglutinin protein (HA) has been studied extensively in humans but less so in other host species. Here, we compared the rates of nucleotide substitution, protein evolution, and glycosylation in the H1 and H3 head and stalk domains among five host classes (avian, canine, equine, human, and swine). For further resolution, we separately analyzed 49 lineages differentiated by host...

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PMID: 38078770
DOI: 10.1128/mbio.02649-23

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