Limitations of lymphoblastoid cell lines for functional analysis of SNPs.

doi:10.1186/s13104-017-2864-6

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Limitations of lymphoblastoid cell lines for functional analysis of SNPs.

BMC research notes - 2 Nov 2017

Pathak Hansi, Frieling Helge, Rhein Mathias, Burkert Alexandra

Abstract excerpt

OBJECTIVE: Single nucleotide polymorphisms (SNPs) are widely linked to the susceptibility and penetrance of diseases. SNP rs886205 (A/G) located in the aldehyde dehydrogenase 2 (ALDH2) promoter is associated with esophageal carcinoma in alcohol-dependent patients. Previously, we found an interaction of the SNP with the methylation of promoter regions as well as the protein levels of ALDH2 in alcohol-dependent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Dehydrogenase, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line

Share to Cells, Cultured

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Genomics

Share to Lymphocytes

Share to Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 29096698
DOI: 10.1186/s13104-017-2864-6
PMCID: PMC5667475

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Limitations of lymphoblastoid cell lines for functional analysis of SNPs.PMID 29096698Read ↗

Impaired Regulation of ALDH2 Protein Expression Revealing a Yet Unknown Epigenetic Impact of rs886205 on Specific Methylation of a Negative Regulatory Promoter Region in Alcohol-Dependent Patients.Semantic proximity Read ↗

Low-risk susceptibility alleles in 40 human breast cancer cell lines.Semantic proximity Read ↗

Promoter Polymorphism rs886205 Genotype Interacts With DNA Methylation of the ALDH2 Regulatory Region in Alcohol Dependence.Semantic proximity Read ↗

MS-HRM assay identifies high levels of epigenetic heterogeneity in human immortalized cell lines.Semantic proximity Read ↗

CD38 expression, function, and gene resequencing in a human lymphoblastoid cell line-based model system.Semantic proximity Read ↗

Human lymphoblastoid cell lines: a goldmine for the biobankomics era.Semantic proximity Read ↗

DLC1 is unlikely to be a primary target for deletions on chromosome arm 8p22 in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoter.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.