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Article

MS-HRM assay identifies high levels of epigenetic heterogeneity in human immortalized cell lines.

Gene - 15 Apr 2015

Putnik Milica, Wojdacz Tomasz K, Pournara Angeliki, Vahter Marie, Wallberg Annika E

Abstract excerpt

Immortalized cell lines are widely used in genetic and epigenetic studies, from exploration of basic molecular pathways to evaluation of disease-specific cellular properties. They are also used in biotechnology, e.g., in drug toxicity tests and vaccine production. Cellular and genetic uniformity is the main feature of immortalized cell lines and it has been particularly advantageous in functional genomic...

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PMID: 25644772
DOI: 10.1016/j.gene.2015.01.063

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