Article
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis.
Nature communications - 20 Jan 2020
Olafsdottir Thorunn A, Theodors Fannar, Bjarnadottir Kristbjorg, Bjornsdottir Unnur Steina, Agustsdottir Arna B, Stefansson Olafur A, Ivarsdottir Erna V, Sigurdsson Jon K, Benonisdottir Stefania, Eyjolfsson Gudmundur I, Gislason David, Gislason Thorarinn, Guðmundsdóttir Steinunn, Gylfason Arnaldur, Halldorsson Bjarni V, Halldorsson Gisli H, Juliusdottir Thorhildur, Kristinsdottir Anna M, Ludviksdottir Dora, Ludviksson Bjorn R, Masson Gisli, Norland Kristjan, Onundarson Pall T, Olafsson Isleifur, Sigurdardottir Olof, Stefansdottir Lilja, Sveinbjornsson Gardar, Tragante Vinicius, Gudbjartsson Daniel F, Thorleifsson Gudmar, Sulem Patrick, Thorsteinsdottir Unnur, Norddahl Gudmundur L, Jonsdottir Ingileif, Stefansson Kari
Abstract excerpt
Asthma is one of the most common chronic diseases affecting both children and adults. We report a genome-wide association meta-analysis of 69,189 cases and 702,199 controls from Iceland and UK biobank. We find 88 asthma risk variants at 56 loci, 19 previously unreported, and evaluate their effect on other asthma and allergic phenotypes. Of special interest are two low frequency variants associated with protection...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.