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Article

Influence of ABCB11 and HNF4α genes on daclatasvir plasma concentration: preliminary pharmacogenetic data from the Kineti-C study.

The Journal of antimicrobial chemotherapy - 1 Oct 2017

Cusato Jessica, De Nicolò Amedeo, Boglione Lucio, Favata Fabio, Ariaudo Alessandra, Mornese Pinna Simone, Guido Federica, Avataneo Valeria, Carcieri Chiara, Cariti Giuseppe, Di Perri Giovanni, D'Avolio Antonio

Abstract excerpt

Background: Daclatasvir is an inhibitor of HCV non-structural 5A protein and is a P-glycoprotein substrate. Pharmacogenetics has had a great impact on previous anti-HCV therapies, particularly considering the association of IL-28B polymorphisms with dual therapy outcome. Objectives: We investigated the association between daclatasvir plasma concentrations at 2 weeks and 1 month of therapy and genetic variants...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 11
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29091211
DOI: 10.1093/jac/dkx237

Genes

ABCB11
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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