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Vitamin D pathway gene polymorphisms and hepatocellular carcinoma in chronic hepatitis C-affected patients treated with new drugs.

Cancer chemotherapy and pharmacology - 1 Mar 2018

Cusato Jessica, Boglione Lucio, De Nicolò Amedeo, Favata Fabio, Ariaudo Alessandra, Mornese Pinna Simone, Guido Federica, Avataneo Valeria, Cantù Marco, Carcieri Chiara, Cariti Giuseppe, Di Perri Giovanni, D'Avolio Antonio

Abstract excerpt

PURPOSE: Since HCV infection may lead to hepatocellular carcinoma (HCC) and vitamin D (deficiency) is related to cancer, we investigated if SNPs in genes involved in vitamin D pathway could predict HCV-related HCC presence in patients treated with new anti-HCV drugs. METHODS: Patients with chronic hepatitis C and treated with direct-acting antivirals were enrolled. SNPs in VDR, CYP27B1, CYP24A1 and GC genes were...

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Share to 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C, Chronic

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Share to Receptors, Calcitriol

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Identifiers

PMID: 29356898
DOI: 10.1007/s00280-018-3520-0

Genes

VDR

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