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Article

ABCB11 and ABCB1 gene polymorphisms impact on telaprevir pharmacokinetic at one month of therapy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Feb 2015

Cusato Jessica, Allegra Sarah, De Nicolò Amedeo, Boglione Lucio, Fatiguso Giovanna, Cariti Giuseppe, Ciancio Alessia, Smedile Antonina, Strona Silvia, Troshina Giulia, Rizzetto Mario, Di Perri Giovanni, D'Avolio Antonio

Abstract excerpt

In 2011 direct-acting antivirals, including telaprevir, have been developed to achieve a better antiviral effect. It was reported that telaprevir is a substrate of P-glycoprotein (ABCB1) and cytochrome P450 3A4. The aim of this retrospective study was the evaluation of the influence of some single nucleotide polymorphisms (SNPs) of genes (ABCB1, SLC28A2/3, SLC29A1) involved in TLV and RBV transport and their...

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Source

Identifiers

PMID: 25661339
DOI: 10.1016/j.biopha.2014.11.007

Genes

ABCB1
ABCB11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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