Article
The vitamin D receptor gene bAt (CCA) haplotype impairs the response to pegylated-interferon/ribavirin-based therapy in chronic hepatitis C patients.
Antiviral therapy - 1 Jan 2012
Baur Katharina, Mertens Joachim C, Schmitt Johannes, Iwata Rika, Stieger Bruno, Frei Pascal, Seifert Burkhardt, Bischoff Ferrari Heike A, von Eckardstein Arnold, Müllhaupt Beat, Geier Andreas
Abstract excerpt
BACKGROUND: Chronic hepatitis C infection is a major cause of end-stage liver disease. Therapy outcome is influenced by 25-OH vitamin D deficiency. To further address this observation, our study investigates the impact of the vitamin D receptor (NR1I1) haplotype and combined effects of plasma vitamin D levels in a well-described cohort of hepatitis C patients. METHODS: A total of 155 chronic hepatitis C patients...
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