Article
Role of pharmacogenetic in ribavirin outcome prediction and pharmacokinetics in an Italian cohort of HCV-1 and 4 patients.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Feb 2015
Allegra Sarah, Cusato Jessica, De Nicolò Amedeo, Boglione Lucio, Gatto Alberto, Cariti Giuseppe, Di Perri Giovanni, D'Avolio Antonio
Abstract excerpt
Ribavirin is phosphorylated by adenosine kinase 1 (AK1) and cytosolic 5'-nucleotidase 2 and it is transported into cells by concentrative nucleoside transporters (CNT) 2/3, coded by SLC28A2/3 genes, and equilibrative nucleoside transporters (ENT) 1/2, coded by SLC29A1/2 genes. We evaluated the association of some polymorphisms of IL28B, SLC28A2/3, SLC29A1, ABCB1, NT5C2, AK1, HNF4α genes and ribavirin treatment...
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