Article
Prevalence of Aflatoxin-Associated TP53R249S Mutation in Hepatocellular Carcinoma in Hispanics in South Texas.
Cancer prevention research (Philadelphia, Pa.) - 1 Feb 2018
Jiao Jingjing, Niu Weibo, Wang Ying, Baggerly Keith, Ye Yuanqing, Wu Xifeng, Davenport Dewitt, Almeda Jose Luis, Betancourt-Garcia Monica M, Forse R Armour, Stevenson Heather L, Watt Gordon P, McCormick Joseph B, Fisher-Hoch Susan P, Beretta Laura
Abstract excerpt
We aimed to determine whether aflatoxin dietary exposure plays a role in the high incidence of hepatocellular carcinoma (HCC) observed among Hispanics in South Texas. We measured TP53R249S somatic mutation, hallmark of aflatoxin etiology in HCC, using droplet digital PCR and RFLP. TP53R249S mutation was detected in 3 of 41 HCC tumors from Hispanics in South Texas (7.3%). We also measured TP53R249S mutation in...
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