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Article

Somatic Mutations in Circulating Cell-Free DNA and Risk for Hepatocellular Carcinoma in Hispanics.

International journal of molecular sciences - 10 Jul 2021

Jiao Jingjing, Sanchez Jessica I, Thompson Erika J, Mao Xizeng, McCormick Joseph B, Fisher-Hoch Susan P, Futreal P Andrew, Zhang Jianhua, Beretta Laura

Abstract excerpt

Hispanics are disproportionally affected by liver fibrosis and hepatocellular carcinoma (HCC). Advanced liver fibrosis is a major risk factor for HCC development. We aimed at identifying somatic mutations in plasma cell-free DNA (cfDNA) of Hispanics with HCC and Hispanics with advanced liver fibrosis but no HCC. Targeted sequencing of over 262 cancer-associated genes identified nonsynonymous mutations in 22 of...

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Identifiers

PMID: 34299031
DOI: 10.3390/ijms22147411
PMCID: PMC8304329

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