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Article

Keratinocytes from Gorlin Syndrome-induced pluripotent stem cells are resistant against UV radiation.

Medical molecular morphology - 1 Jun 2021

Morita Nana, Onodera Shoko, Nakamura Yuriko, Nakamura Takashi, Takahashi Shin-Ichi, Nomura Takeshi, Azuma Toshifumi

Abstract excerpt

Gorlin syndrome (GS) is an autosomal dominant genetic disorder involving Patched 1 (PTCH1) mutations. The PTCH1 is a receptor as well as an inhibitor of hedgehog (Hh) to sequester downstream Hh pathway molecules called Smoothened (SMO). PTCH1 mutations causes a variety of GS conditions including falx calcification, odontogenic keratocytes and basal cell carcinomas (BCC). Because PTCH1 is a major driver gene of...

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PMID: 32816116
DOI: 10.1007/s00795-020-00264-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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