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Association of DRD2, DRD4 and COMT genes variants and their gene-gene interactions with antipsychotic treatment response in patients with schizophrenia.

BMC psychiatry - 25 Oct 2023

Taheri Narges, Pirboveiri Rokhshid, Sayyah Mehdi, Bijanzadeh Mahdi, Ghandil Pegah

Abstract excerpt

Antipsychotic drugs are the first line of treatment in schizophrenia; although antipsychotic responses indicate a wide interindividual variety in patients with schizophrenia. This study aimed to investigate the association between four polymorphisms in DRD2, DRD4 and COMT genes and their gene-gene interactions with antipsychotic treatment response in patients with schizophrenia. A total of 101 patients with...

Topics

Humans
Antipsychotic Agents
Catechol O-Methyltransferase
Epistasis, Genetic
Genotype
Polymorphism, Genetic
Receptors, Dopamine D2
Receptors, Dopamine D4
Schizophrenia

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Identifiers

PMID: 37880658
DOI: 10.1186/s12888-023-05292-9
PMCID: PMC10599059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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