Article
BRCA1-Associated Protein 1 (BAP1) Immunohistochemical Expression as a Diagnostic Tool in Malignant Pleural Mesothelioma Classification: A Large Retrospective Study.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Nov 2016
Righi Luisella, Duregon Eleonora, Vatrano Simona, Izzo Stefania, Giorcelli Jessica, Rondón-Lagos Milena, Ascoli Valeria, Ruffini Enrico, Ventura Laura, Volante Marco, Papotti Mauro, Scagliotti Giorgio Vittorio
Abstract excerpt
INTRODUCTION: Malignant pleural mesothelioma (MPM) is a highly aggressive disease with limited therapeutic options. Histological subtype remains among the most reliable prognostic factors, because the epithelioid subtype associated with the best prognosis and the sarcomatoid subtype with the worst. The biphasic subtype has an intermediate prognosis, but its definitive histological diagnosis may be challenging...
Topics
- BRCA1 Protein
- Biomarkers, Tumor
- Female
- Humans
- Immunohistochemistry
- Lung Neoplasms
- Male
- Mesothelioma
- Mesothelioma, Malignant
- Mutation
- Pleural Neoplasms
- Prognosis