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Article

PINK1-dependent NFKB signaling contributes to amyloid pathology in Alzheimer disease

4 May 2025

Abstract excerpt

Mitochondrial dysfunction plays a preponderant role in the development of Alzheimer disease (AD). We have demonstrated that activation of PINK1 (PTEN induced kinase 1)-dependent mitophagy ameliorates amyloid pathology, attenuates mitochondrial and synaptic dysfunction, and improves cognitive function. However, the underlying mechanisms remain largely unknown. Using a newly generated PINK1-AD transgenic mouse...

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PMID: 40320714
DOI: 10.1080/15548627.2025.2463322

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