Article

Mechanisms Associated with PINK1 Mutations in Parkinson's Disease

2025-10-20

Abstract excerpt

Abstract Parkinson’s disease (PD) is a widespread and progressively debilitating neurodegenerative disorder, with its global prevalence steadily increasing. Central to its pathogenesis is the PINK1 gene (PTEN-induced putative kinase 1), which plays a pivotal role in mitochondrial function and protecting cells from oxidative stress-induced apoptosis. This review explores the complex relationship between PINK1 mutat...

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Literature Corpus work: f34da027-8aa8-58eb-9c36-8e0e253776fa
DOI: 10.12688/f1000research.170090.1

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