Article
Estimation of cis-eQTL effect sizes using a log of linear model.
Biometrics - 1 Jun 2018
Palowitch John, Shabalin Andrey, Zhou Yi-Hui, Nobel Andrew B, Wright Fred A
Abstract excerpt
The study of expression Quantitative Trait Loci (eQTL) is an important problem in genomics and biomedicine. While detection (testing) of eQTL associations has been widely studied, less work has been devoted to the estimation of eQTL effect size. To reduce false positives, detection methods frequently rely on linear modeling of rank-based normalized or log-transformed gene expression data. Unfortunately, these...
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