Article
A systematic comparison of normalization methods for eQTL analysis.
Briefings in bioinformatics - 5 Nov 2021
Yang Jiajun, Wang Dongyang, Yang Yanbo, Yang Wenqian, Jin Weiwei, Niu Xiaohui, Gong Jing
Abstract excerpt
Expression quantitative trait loci (eQTL) analysis has been widely used in interpreting disease-associated loci through correlating genetic variant loci with the expression of specific genes. RNA-sequencing (RNA-Seq), which can quantify gene expression at the genome-wide level, is often used in eQTL identification. Since different normalization methods of gene expression have substantial impacts on RNA-seq...
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