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Article

Biogenesis and iron-dependency of ribosomal RNA hydroxylation.

Nucleic acids research - 15 Dec 2017

Kimura Satoshi, Sakai Yusuke, Ishiguro Kensuke, Suzuki Tsutomu

Abstract excerpt

Post-transcriptional modifications of ribosomal RNAs (rRNAs) are involved in ribosome biogenesis and fine-tuning of translation. 5-Hydroxycytidine (ho5C), a modification of unknown biogenesis and function, is present at position 2501 of Escherichia coli 23S rRNA. We conducted a genome-wide screen in E. coli to identify genes required for ho5C2501 formation, and found a previously-uncharacterized gene, ydcP...

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PMID: 29069499
DOI: 10.1093/nar/gkx969
PMCID: PMC5727448

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