Article
Identification of 5-hydroxycytidine at position 2501 concludes characterization of modified nucleotides in E. coli 23S rRNA.
Journal of molecular biology - 19 Aug 2011
Havelund Jesper Foged, Giessing Anders Michael Bernth, Hansen Trine, Rasmussen Anette, Scott Lincoln Greyson, Kirpekar Finn
Abstract excerpt
Complete characterization of a biomolecule's chemical structure is crucial in the full understanding of the relations between their structure and function. The dominating components in ribosomes are ribosomal RNAs (rRNAs), and the entire rRNA-but a single modified nucleoside at position 2501 in 23S rRNA-has previously been characterized in the bacterium Escherichia coli. Despite a first report nearly 20 years...
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