KLF10 gene expression is associated with high fetal hemoglobin levels and with response to hydroxyurea treatment in β-hemoglobinopathy patients.

doi:10.2217/pgs.12.125

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Article

KLF10 gene expression is associated with high fetal hemoglobin levels and with response to hydroxyurea treatment in β-hemoglobinopathy patients.

Pharmacogenomics - 1 Oct 2012

Borg Joseph, Phylactides Marios, Bartsakoulia Marina, Tafrali Christina, Lederer Carsten, Felice Alexander E, Papachatzopoulou Adamantia, Kourakli Alexandra, Stavrou Eleana F, Christou Soteroula, Hou Jun, Karkabouna Sophia, Lappa-Manakou Christina, Ozgur Zeliha, van Ijcken Wilfred, von Lindern Marieke, Grosveld Frank G, Georgitsi Marianthi, Kleanthous Marina, Philipsen Sjaak, Patrinos George P

Abstract excerpt

AIM: In humans, fetal hemoglobin (HbF) production is controlled by many intricate mechanisms that, to date, remain only partly understood. PATIENTS & METHODS: Pharmacogenomic analysis of the effects of hydroxyurea (HU) on HbF production was undertaken in a collection of Hellenic β-thalassemia and sickle cell disease (SCD) compound heterozygotes and a collection of healthy and KLF1-haploinsufficient Maltese...

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PMID: 23057549
DOI: 10.2217/pgs.12.125

Genes

KLF10
SCD
KLF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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