Article
BCL-XL directly modulates RAS signalling to favour cancer cell stemness.
Nature communications - 24 Oct 2017
Carné Trécesson Sophie de, Souazé Frédérique, Basseville Agnès, Bernard Anne-Charlotte, Pécot Jessie, Lopez Jonathan, Bessou Margaux, Sarosiek Kristopher A, Letai Anthony, Barillé-Nion Sophie, Valo Isabelle, Coqueret Olivier, Guette Catherine, Campone Mario, Gautier Fabien, Juin Philippe Paul
Abstract excerpt
In tumours, accumulation of chemoresistant cells that express high levels of anti-apoptotic proteins such as BCL-XL is thought to result from the counter selection of sensitive, low expresser clones during progression and/or initial treatment. We herein show that BCL-XL expression is selectively advantageous to cancer cell populations even in the absence of pro-apoptotic pressure. In transformed human mammary...
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