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Article

Bcl-xL promotes metastasis independent of its anti-apoptotic activity

20 Jan 2016

Abstract excerpt

Bcl-xL suppresses mitochondria-mediated apoptosis and is frequently overexpressed in cancer to promote cancer cell survival. Bcl-xL also promotes metastasis. However, it is unclear whether this metastatic function is dependent on its anti-apoptotic activity in the mitochondria. Here we demonstrate that Bcl-xL promotes metastasis independent of its anti-apoptotic activity. We show that apoptosis-defective Bcl-xL...

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PMID: 26785948
DOI: 10.1038/ncomms10384

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