Article
Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.
Nature cell biology - 1 Oct 2017
Wu Xiaofeng, Zhang Li-Shu, Toombs Jason, Kuo Yi-Chun, Piazza John Tyler, Tuladhar Rubina, Barrett Quinn, Fan Chih-Wei, Zhang Xuewu, Walensky Loren D, Kool Marcel, Cheng Steven Y, Brekken Rolf, Opferman Joseph T, Green Douglas R, Moldoveanu Tudor, Lum Lawrence
Abstract excerpt
Direct interactions between pro- and anti-apoptotic BCL-2 family members form the basis of cell death decision-making at the outer mitochondrial membrane (OMM). Here we report that three anti-apoptotic BCL-2 proteins (MCL-1, BCL-2 and BCL-XL) found untethered from the OMM function as transcriptional regulators of a prosurvival and growth program. Anti-apoptotic BCL-2 proteins engage a BCL-2 homology (BH) domain...
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