Article
The effect of genetic variants on the relationship between statins and breast cancer in postmenopausal women in the Women's Health Initiative observational study.
Breast cancer research and treatment - 1 Feb 2018
Bock Cathryn H, Jay Allison M, Dyson Gregory, Beebe-Dimmer Jennifer L, Cote Michele L, Hou Lifang, Howard Barbara V, Desai Pinkal, Purrington Kristen, Prentice Ross, Simon Michael S
Abstract excerpt
PURPOSE: Statins have been postulated to have chemopreventive activity against breast cancer. We evaluated whether germline genetic polymorphisms modified the relationship between statins and breast cancer risk using data from the Women's Health Initiative. We evaluated these interactions using both candidate gene and agnostic genome-wide approaches. METHODS: To identify candidate gene-statin interactions, we...
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