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Article

Predictive pharmacogenetic biomarkers for breast cancer recurrence prevention by simvastatin.

Acta oncologica (Stockholm, Sweden) - 1 Sept 2020

Ahern Thomas P, Damkier Per, Feddersen Søren, Kjærsgaard Anders, Lash Timothy L, Hamilton-Dutoit Stephen, Lythjohan Cathrine Bredal, Ejlertsen Bent, Christiansen Peer M, Cronin-Fenton Deirdre P

Abstract excerpt

Background: Statins treat hyperlipidemia and prevent cardiovascular morbidity and mortality. Evidence suggests that they also have anti-neoplastic activity. Several studies show a reduced rate of breast cancer recurrence among lipophilic statin users (e.g., simvastatin), motivating calls for clinical trials of statins in breast cancer patients. We measured the impact of genetic variation in statin-metabolizing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32351149
DOI: 10.1080/0284186X.2020.1759820
PMCID: PMC7483991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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