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Alcohol Consumption Does not Modify the Polygenic Risk Score-Based Genetic Risk of Breast Cancer in Postmenopausal Women: Atherosclerosis Risk in Communities Study.

Cancer prevention research (Philadelphia, Pa.) - 3 Feb 2025

Zhang Minghui, Ru Meng, Zhang Jingning, Wang Ziqiao, Lu Jiayun, Butler Kenneth R, Chatterjee Nilanjan, Couper David J, Prizment Anna E, Soori Mehrnoosh M, Visvanathan Kala, Zahnow Cynthia A, Joshu Corinne E, Platz Elizabeth A

Abstract excerpt

High genetic risk and alcohol consumption ≥1 drink/day are associated with increased breast cancer risk. However, the interaction between alcohol and genetics on breast cancer risk is poorly understood, including in populations not enriched with daily drinkers. We prospectively studied 5,651 White and Black postmenopausal women in the Atherosclerosis Risk in Communities study. Alcohol intake was assessed by a...

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Identifiers

PMID: 39676351
DOI: 10.1158/1940-6207.CAPR-24-0208
PMCID: PMC11790378

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