Genetic meta-analysis of cancer diagnosis following statin use identifies new associations and implicates human leukocyte antigen (HLA) in women.

doi:10.1038/s41397-021-00221-z

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genetic meta-analysis of cancer diagnosis following statin use identifies new associations and implicates human leukocyte antigen (HLA) in women.

The pharmacogenomics journal - 1 Aug 2021

Sun Maxine, Lemaçon Audrey, Legault Marc-André, Asselin Géraldine, Provost Sylvie, Aschard Hugues, Barhdadi Amina, Zada Yassamin Feroz, Valois Diane, Mongrain Ian, Tardif Jean-Claude, Dubé Marie-Pierre

Abstract excerpt

We sought to perform a genomic evaluation of the risk of incident cancer in statin users, free of cancer at study entry. Patients who previously participated in two phase IV trials (TNT and IDEAL) with genetic data were used (npooled = 11,196). A GWAS meta-analysis using Cox modeling for the prediction of incident cancer was conducted in the pooled cohort and sex-stratified. rs13210472 (near HLA-DOA gene) was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coronary Artery Disease

Share to Genomics

Share to HLA Antigens

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Neoplasms

Share to Proportional Hazards Models

Share to Randomized Controlled Trials as Topic

Source

Open in PubMed

Identifiers

PMID: 33649522
DOI: 10.1038/s41397-021-00221-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Genetic meta-analysis of cancer diagnosis following statin use identifies new associations and implicates human leukocyte antigen (HLA) in women.PMID 33649522Read ↗

Predicting the effect of statins on cancer risk using genetic variants from a Mendelian randomization study in the UK Biobank.Semantic proximity Read ↗

Genetic variants modulate gene expression statin response in human lymphoblastoid cell linesSemantic proximity Read ↗

The effect of genetic variants on the relationship between statins and breast cancer in postmenopausal women in the Women's Health Initiative observational study.Semantic proximity Read ↗

Epigenetic Link Between Statin Therapy and Type 2 Diabetes.Semantic proximity Read ↗

The role of genetic predisposition in cardiovascular risk after cancer diagnosis: a matched cohort study of the UK Biobank.Semantic proximity Read ↗

Genome-wide association analysis of incident coronary heart disease (CHD) in African Americans: a short report.Semantic proximity Read ↗

Statin therapy is associated with epigenetic modifications in individuals with Type 2 diabetesSemantic proximity Read ↗

Effect of statins and testosterone replacement therapy on incident cardiovascular disease among male hormone-related cancer survivorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.