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Article

Thymic-Specific Serine Protease Limits Central Tolerance and Exacerbates Experimental Autoimmune Encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2017

Serre Laurent, Girard Maeva, Ramadan Abdoulraouf, Menut Paul, Rouquié Nelly, Lucca Liliana E, Mahiddine Karim, Leobon Bertrand, Mars Lennart T, Guerder Sylvie

Abstract excerpt

The genetic predisposition to multiple sclerosis (MS) is most strongly conveyed by MHC class II haplotypes, possibly by shaping the autoimmune CD4 T cell repertoire. Whether Ag-processing enzymes contribute to MS susceptibility by editing the peptide repertoire presented by these MHC haplotypes is unclear. Thymus-specific serine protease (TSSP) is expressed by thymic epithelial cells and thymic dendritic cells...

Read the complete abstract on PubMed

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Share to Encephalomyelitis, Autoimmune, Experimental
Share to Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred NOD

Share to Mice, SCID

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Share to Myelin-Oligodendrocyte Glycoprotein

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Source

Identifiers

PMID: 29061767
DOI: 10.4049/jimmunol.1700667

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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