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Article

Multilayered Omics-Based Analysis of a Head and Neck Cancer Model of Cisplatin Resistance Reveals Intratumoral Heterogeneity and Treatment-Induced Clonal Selection.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2018

Niehr Franziska, Eder Theresa, Pilz Tanja, Konschak Robert, Treue Denise, Klauschen Frederick, Bockmayr Michael, Türkmen Seval, Jöhrens Korinna, Budach Volker, Tinhofer Ingeborg

Abstract excerpt

Purpose: Platinum-based drugs, in particular cisplatin (cis-diamminedichloridoplatinum(II), CDDP), are used for treatment of squamous cell carcinoma of the head and neck (SCCHN). Despite initial responses, CDDP treatment often results in chemoresistance, leading to therapeutic failure. The role of primary resistance at subclonal level and treatment-induced clonal selection in the development of CDDP resistance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29061642
DOI: 10.1158/1078-0432.CCR-17-2410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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