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AML-specific cytotoxic antibodies in patients with durable graft-versus-leukemia responses

23 Oct 2017

Abstract excerpt

Most patients with acute myeloid leukemia (AML) can only be cured when allogeneic hematopoietic stem-cell transplantation induces a graft-versus-leukemia immune response (GVL). Although the role of T cells and natural killer cells in tumor immunology has been established, less is known about the contribution of B cells. From B cells of high-risk patients with AML with potent and lasting GVL responses, we isolated...

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PMID: 29061569
DOI: 10.1182/blood-2017-02-768762

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