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Immunotherapy-Based Targeting and Elimination of Leukemic Stem Cells in AML and CML

29 Aug 2019

Abstract excerpt

The concept of leukemic stem cells (LSC) has been developed with the idea to explain the clonal hierarchies and architectures in leukemia, and the more or less curative anti-neoplastic effects of various targeted drugs. It is now widely accepted that curative therapies must have the potential to eliminate or completely suppress LSC, as only these cells can restore and propagate the malignancy for unlimited time...

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PMID: 31470642
DOI: 10.3390/ijms20174233

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