Back to search

Article

Use of human AML cells to study graft-versus-leukemia immunity in xenogeneic mouse models of GVHD

2024-05-02

Abstract excerpt

Allogeneic hematopoietic cell transplantation (allo-HCT) is the main therapeutic approach for patients with high-risk acute myeloid leukemia (AML), but the rate of relapse remains high and is associated with poor outcomes. Discovering new approaches to maximize the graft-versus-leukemia (GVL) effects while mitigating graft-versus-host disease (GVHD) should therefore be pursued. Because of the difficulties in model...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
76aa8e8a-5692-5d5a-9804-63118a29d382
DOI
10.1101/2024.04.30.591828
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Use of human AML cells to study graft-versus-leukemia immunity in xenogeneic mouse models of GVHDDOI 10.1101/2024.04.30.591828
Human acute myeloid leukemia stem cells.Semantic proximity
Leukemia stem cellsSemantic proximity
Evolution of Allogeneic Stem Cell Transplantation: Main Focus on AMLSemantic proximity
Patient-Derived Intrafemoral Orthotopic Xenografts of Peripheral Blood or Bone Marrow from Acute Myeloid and Acute Lymphoblastic Leukemia Patients: Clinical Characterization, Methodology, and ValidationSemantic proximity
Development of a Multi-Step Leukemogenesis Model of MLL-Rearranged Leukemia Using Humanized MiceSemantic proximity
Concise Review: The Role of Hematopoietic Stem Cell Transplantation in the Treatment of Acute Myeloid LeukemiaSemantic proximity
Modeling the Initiation and Progression of Human Acute Leukemia in MiceSemantic proximity
Murine Models of Acute Myeloid LeukaemiaSemantic proximity
Human AML cells in NOD/SCID mice: engraftment potential and gene expressionSemantic proximity
Intra-peritoneal transplantation for efficient and easy generation of experimental acute myeloid leukemia in miceSemantic proximity
Transplantation of human acute myeloid leukemia (AML) cells in immunodeficient mice reveals altered cell surface phenotypes and expression of human endothelial markers.Semantic proximity
A platform of robust patient-derived leukemia models covering subgroups for which no cell lines existSemantic proximity
Select a neighboring publication to make it the new centre.