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Article

Characterization of a catalytically efficient acidic RNA-cleaving deoxyribozyme.

Nucleic acids research - 1 Jan 2005

Kandadai Srinivas A, Li Yingfu

Abstract excerpt

We previously demonstrated--through the isolation of RNA-cleaving deoxyribozymes by in vitro selection that are catalytically active in highly acidic solutions--that DNA, despite its chemical simplicity, could perform catalysis under challenging chemical conditions [Liu,Z., Mei,S.H., Brennan,J.D. and Li,Y. (2003) J. Am. Chem. Soc. 125, 7539-7545]. One remarkable DNA molecule therefrom is pH4DZ1, a self-cleaving...

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Identifiers

PMID: 16391005
DOI: 10.1093/nar/gki1013
PMCID: PMC1325019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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