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Mining biosynthetic gene clusters in Paenibacillus genomes to discover novel antibiotics

27 Jun 2024

Abstract excerpt

BACKGROUND: Bacterial antimicrobial resistance poses a severe threat to humanity, necessitating the urgent development of new antibiotics. Recent advances in genome sequencing offer new avenues for antibiotic discovery. Paenibacillus genomes encompass a considerable array of antibiotic biosynthetic gene clusters (BGCs), rendering these species as good candidates for genome-driven novel antibiotic exploration....

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PMID: 38937695
DOI: 10.1186/s12866-024-03375-5

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