Article
The association of clinicopathological features and survival in colorectal cancer patients with kras mutation status.
Journal of cancer research and therapeutics - 1 Jan 2000
Akman Tulay, Oztop Ilhan, Baskin Yasemin, Unek Ilkay Tugba, Demir Necla, Ellidokuz Hulya, Yilmaz Ahmet Ugur
Abstract excerpt
BACKGROUND: KRAS mutations have a significant role in the consecutive activation of RAS.RAF.MEK.ERK pathway in colorectal cancer.Approximately 30.35% of sporadic colorectal cancers have KRAS mutation. While the predictive role of KRAS is commonly accepted at the present time, its prognostic role and association with different clinical and histopathological properties are currently unclear and inconsistent. The...
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