Article
Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance.
Nature genetics - 1 Oct 2013
Zhang Hongtai, Li Dongfang, Zhao Lili, Fleming Joy, Lin Nan, Wang Ting, Liu Zhangyi, Li Chuanyou, Galwey Nicholas, Deng Jiaoyu, Zhou Ying, Zhu Yuanfang, Gao Yunrong, Wang Tong, Wang Shihua, Huang Yufen, Wang Ming, Zhong Qiu, Zhou Lin, Chen Tao, Zhou Jie, Yang Ruifu, Zhu Guofeng, Hang Haiying, Zhang Jia, Li Fabin, Wan Kanglin, Wang Jun, Zhang Xian-En, Bi Lijun
Abstract excerpt
The worldwide emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis threatens to make this disease incurable. Drug resistance mechanisms are only partially understood, and whether the current understanding of the genetic basis of drug resistance in M. tuberculos...
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