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Article

Specificity of <em>Escherichia coli</em> Heat-Labile Enterotoxin Investigated by Single-Site Mutagenesis and Crystallography

2019-01-28

Abstract excerpt

Diarrhoea caused by enterotoxigenic Escherichia coli is one of the leading causes of mortality in children under five years of age and is a great burden on developing countries. The major virulence factor of the bacterium is the heat-labile enterotoxin (LT), a close homologue of the cholera toxin. The toxins bind to carbohydrate receptors in the gastrointestinal tract, leading to toxin uptake and, ultimately, to s...

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Identifiers and source

Literature Corpus work
753080dc-abe5-59a5-899b-351dca13a818
DOI
10.20944/preprints201812.0236.v2
Open publication

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Specificity of <em>Escherichia coli</em> Heat-Labile Enterotoxin Investigated by Single-Site Mutagenesis and CrystallographyDOI 10.20944/preprints201812.0236.v2
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