Article
Immunity protein release from a cell-bound nuclease colicin complex requires global conformational rearrangement.
MicrobiologyOpen - 1 Oct 2013
Vankemmelbeke Mireille, Housden Nicholas G, James Richard, Kleanthous Colin, Penfold Christopher N
Abstract excerpt
Nuclease colicins bind their target receptor BtuB in the outer membrane of sensitive Escherichia coli cells in the form of a high-affinity complex with their cognate immunity proteins. The release of the immunity protein from the colicin complex is a prerequisite for cell entry of the colicin and occurs via a process that is still relatively poorly understood. We have previously shown that an energy input in the...
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