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Article

Ecd promotes U5 snRNP maturation and Prp8 stability.

Nucleic acids research - 22 Feb 2021

Erkelenz Steffen, Stanković Dimitrije, Mundorf Juliane, Bresser Tina, Claudius Ann-Katrin, Boehm Volker, Gehring Niels H, Uhlirova Mirka

Abstract excerpt

Pre-mRNA splicing catalyzed by the spliceosome represents a critical step in the regulation of gene expression contributing to transcriptome and proteome diversity. The spliceosome consists of five small nuclear ribonucleoprotein particles (snRNPs), the biogenesis of which remains only partially understood. Here we define the evolutionarily conserved protein Ecdysoneless (Ecd) as a critical regulator of U5 snRNP...

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Identifiers

PMID: 33444449
DOI: 10.1093/nar/gkaa1274
PMCID: PMC7897482

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